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TitleCryo-EM structure of human TMEM45B with a bound GM3 (18:1;O2/24:1).
Journal, issue, pagesJ Struct Biol, Vol. 218, Issue 4, Page 108376, Year 2026
Publish dateSep 24, 2026
AuthorsMariana Grieben / Julica Inderhees / Niklas Ebersberger /
PubMed AbstractThe orphan transmembrane protein 45B (TMEM45B) has been reported to be involved in mechanical pain hypersensitivity, antiviral processes, and cancer. The structure of human TMEM45B with bound ...The orphan transmembrane protein 45B (TMEM45B) has been reported to be involved in mechanical pain hypersensitivity, antiviral processes, and cancer. The structure of human TMEM45B with bound monosialodihexosylganglioside (GM3, 18:1;O2/24:1), presented here, determined by single-particle cryo-electron microscopy (cryo-EM) to 2.8 Å, reveals a homotetrameric assembly of seven-transmembrane-helix protomers. The first six transmembrane helices from each protomer create a central hydrophobic tunnel that accommodates metal ions and the C24:1 fatty acid component of the ganglioside GM3.
External linksJ Struct Biol / PubMed:42785650
MethodsEM (single particle)
Resolution2.82 Å
Structure data

56439

9tyv

EMDB-56439, PDB-9tyv:
Cryo-EM structure of human TMEM45B with a bound GM3 (18:1;O2/24:1)
Method: EM (single particle) / Resolution: 2.82 Å

Chemicals

ChemComp-UNX:
Unknown entry

PDB-1kb5:
MURINE T-CELL RECEPTOR VARIABLE DOMAIN/FAB COMPLEX

ChemComp-CLR:
CHOLESTEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / orphan transmembrane protein

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