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Structure paper

TitleA ubiquitin chain-feeding mechanism for BRCA1-A
Journal, issue, pagesBiorxiv, Year 2026
Publish dateSep 8, 2025 (structure data deposition date)
AuthorsMurachelli AG / El Oualid F / Sixma TK
External linksBiorxiv / Search PubMed
MethodsEM (single particle)
Resolution3.0 - 3.6 Å
Structure data

55038

9smn

EMDB-55038, PDB-9smn:
BRCA1-A complex bound to K63-polyUbATA - open form StateC StateP
Method: EM (single particle) / Resolution: 3.2 Å

55039

9smp

EMDB-55039, PDB-9smp:
BRCA1-A complex bound to K63-polyUbATA - open form double State P
Method: EM (single particle) / Resolution: 3.0 Å

55041

9sms

EMDB-55041, PDB-9sms:
BRCA1-A complex: Ubiquitin bound to BRE at the wrist site (focused 3D class)
Method: EM (single particle) / Resolution: 3.3 Å

55047

9sna

EMDB-55047, PDB-9sna:
BRCA1-A complex bound to K63-diUbATA - open form StateC StateP
Method: EM (single particle) / Resolution: 3.2 Å

EMDB-55052: Structure of open BRCA1-A complex bound to polyUbATA - focused classification on elbow Ubiquitin
Method: EM (single particle) / Resolution: 3.0 Å

55053

9so9

EMDB-55053, PDB-9so9:
BRCA1-A complex bound to K63-oligoUbATA - closed form StateC*
Method: EM (single particle) / Resolution: 3.4 Å

EMDB-55054: Structure of BRCA1-A complex bound to oligoUbATA - open form
Method: EM (single particle) / Resolution: 3.2 Å

EMDB-55055: Apo BRCA1-A complex in presence of K63-oligoUbATA - closed form
Method: EM (single particle) / Resolution: 3.6 Å

EMDB-55056: BRCA1-A complex bound to K63-polyUbATA - closed form State C*
Method: EM (single particle) / Resolution: 3.4 Å

Chemicals

ChemComp-ZN:
Unknown entry

PDB-1jpl:
GGA3 VHS domain complexed with C-terminal peptide from cation-independent mannose 6-phosphate receptor

Source
  • homo sapiens (human)
KeywordsMETAL BINDING PROTEIN / Deubiquitinase; DNA repair; Metalloprotein; Ubiquitin chains;

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