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Structure paper

TitleAncestral proteins trace the emergence of substrate specificity and oligomerization within bacterial DEDDy dinucleases.
Journal, issue, pagesSci Adv, Vol. 12, Page eaef1581-eaef1581, Year 2026
Publish dateApr 3, 2025 (structure data deposition date)
AuthorsMortensen, S. / Burnim, A.A. / Dufault-Thompson, K. / Lipka, A.E. / Jiang, X. / Sondermann, H.
External linksSci Adv / PubMed:42585308
MethodsX-ray diffraction
Resolution1.45 - 3 Å
Structure data

PDB-9qrf:
Ancestral protein of diDNase
Method: X-RAY DIFFRACTION / Resolution: 1.45 Å

PDB-9qth:
Inquilinus NrnC
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-9rtc:
Okeania NrnC bound to pGG
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

ChemComp-G:
GUANOSINE-5'-MONOPHOSPHATE

ChemComp-NA:
Unknown entry

Source
  • synthetic construct (others)
  • inquilinus limosus (bacteria)
  • okenia (invertebrata)
  • escherichia coli (E. coli)
KeywordsDE NOVO PROTEIN / Ancestor / dinuclease / diDNase / NrnC / HYDROLASE / nuclease

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