Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Crystallographic Fragment Screening with CK2 alpha', an Isoform of Human Protein Kinase CK2 Catalytic Subunit, and Its Use to Obtain a CK2 alpha'/Heparin Complex Structure
Journal, issue, pages	Kinases Phosphatases, Vol. 4, Page 1-, Year 2026
Publish date	Jan 8, 2025 (structure data deposition date)
Authors	Werner, C. / Barthel, T. / Harasimowicz, H. / Marminon, C. / Weiss, M.S. / Borgne, M.L. / Niefind, K.
External links	Kinases Phosphatases / Search PubMed
Methods	X-ray diffraction
Resolution	0.89 - 2.2 Å
Structure data	PDB-9hxu: Protein kinase CK2 catalytic subunit alpha (CSNK2A1 gene product) in complex with F2X-Entry screen fragment C02 Method: X-RAY DIFFRACTION / Resolution: 2.2 Å PDB-9hyh: Protein kinase CK2 catalytic subunit alpha (CSNK2A1 gene product) in complex with F2X-Entry screen fragment D02 and CX-4945 (Silmitasertib) Method: X-RAY DIFFRACTION / Resolution: 1.96 Å PDB-9ihg: Protein kinase CK2 catalytic subunit alpha' (CSNK2A2 gene product) in complex with F2X-Entry screen fragment C02 Method: X-RAY DIFFRACTION / Resolution: 1.08 Å PDB-9ihi: Protein kinase CK2 catalytic subunit alpha' (CSNK2A2 gene product) in complex with F2X-Entry screen fragment D02 Method: X-RAY DIFFRACTION / Resolution: 1.23 Å PDB-9q8c: Protein kinase CK2 catalytic subunit alpha' (CSNK2A2 gene product) in complex with F2X-Entry screen fragment F02 Method: X-RAY DIFFRACTION / Resolution: 0.9 Å PDB-9q8q: Protein kinase CK2 catalytic subunit alpha' (CSNK2A2 gene product) in complex with F2X-Entry screen fragment E03 Method: X-RAY DIFFRACTION / Resolution: 0.98 Å PDB-9q9a: Protein kinase CK2 catalytic subunit alpha' (CSNK2A2 gene product) in complex with F2X-Entry screen fragment C06 and CX-4945 (Silmitasertib) Method: X-RAY DIFFRACTION / Resolution: 1.03 Å PDB-9q9b: Protein kinase CK2 catalytic subunit alpha' (CSNK2A2 gene product) in complex with F2X-Entry screen fragment C07 and CX-4945 (Silmitasertib) Method: X-RAY DIFFRACTION / Resolution: 1.84 Å PDB-9q9c: Protein kinase CK2 catalytic subunit alpha' (CSNK2A2 gene product) in complex with F2X-Entry screen fragment D04 Method: X-RAY DIFFRACTION / Resolution: 1.66 Å PDB-9q9d: Protein kinase CK2 catalytic subunit alpha' (CSNK2A2 gene product) in complex with F2X-Entry screen fragment D06 and CX-4945 (Silmitasertib) Method: X-RAY DIFFRACTION / Resolution: 0.89 Å PDB-9q9g: Protein kinase CK2 catalytic subunit alpha' (CSNK2A2 gene product) in complex with F2X-Entry screen fragment D10 Method: X-RAY DIFFRACTION / Resolution: 0.94 Å PDB-9qab: Protein kinase CK2 catalytic subunit alpha' (CSNK2A2 gene product) in complex with F2X-Entry screen fragment E11 and CX-4945 (Silmitasertib) Method: X-RAY DIFFRACTION / Resolution: 0.95 Å PDB-9qag: Protein kinase CK2 catalytic subunit alpha' (CSNK2A2 gene product) in complex with F2X-Entry screen fragment F08 and CX-4945 (Silmitasertib) Method: X-RAY DIFFRACTION / Resolution: 1.01 Å PDB-9qak: Protein kinase CK2 catalytic subunit alpha' (CSNK2A2 gene product) in complex with F2X-Entry screen fragment G07 Method: X-RAY DIFFRACTION / Resolution: 0.98 Å PDB-9qb0: Protein kinase CK2 catalytic subunit alpha' (CSNK2A2 gene product) in complex with F2X-Entry screen fragment H07 Method: X-RAY DIFFRACTION / Resolution: 1.01 Å PDB-9qb6: Protein kinase CK2 catalytic subunit alpha' (CSNK2A2 gene product) in complex with F2X-Entry screen fragment H02 and CX-4945 (Silmitasertib) Method: X-RAY DIFFRACTION / Resolution: 1.05 Å
Chemicals	ChemComp-SYA: 2,4,5-tris(fluoranyl)-3-methoxy-benzoic acid ChemComp-SO4: SULFATE ION ChemComp-CL: Unknown entry ChemComp-HOH: WATER ChemComp-SY4: ~{N}-[5-azanyl-2,4-bis(fluoranyl)phenyl]propane-1-sulfonamide ChemComp-3NG: 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid ChemComp-T9Y: ethyl 5-(trifluoromethyl)-1H-pyrazole-4-carboxylate PDB-1i4n: CRYSTAL STRUCTURE OF INDOLEGLYCEROL PHOSPHATE SYNTHASE FROM THERMOTOGA MARITIMA PDB-1i4v: SOLUTION STRUCTURE OF THE UMUD' HOMODIMER ChemComp, No image ChemComp-VN9: Unknown entry ChemComp, No image ChemComp-R9D: Unknown entry ChemComp-EDO: 1,2-ETHANEDIOL ChemComp-R9G: (3-methoxyphenyl)(pyrrolidin-1-yl)methanone ChemComp-R9J: 2-methyl-N-(4-methylphenyl)-L-alanine ChemComp-RA7: [2-(morpholin-4-yl)-1,3-thiazol-5-yl]methanol ChemComp-RBJ: 4-[(methylamino)methyl]phenol PDB-1i5i: THE C18S MUTANT OF BOVINE (GAMMA-B)-CRYSTALLIN ChemComp, No image ChemComp-U8X: Unknown entry ChemComp-RDV: 3-cyclopentyl-1-(piperazin-1-yl)propan-1-one
Source	homo sapiens (human)
Keywords	TRANSFERASE / Protein kinase CK2 / kinase / fragment-based screening / ligand / casein kinase II / CK2 / protein kinase