Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Mechanistic insights into the therapeutic properties of delta opioid receptor.
Journal, issue, pages	Sci Adv, Vol. 12, Issue 13, Page eaeb6737, Year 2026
Publish date	Mar 27, 2026
Authors	Sarah M Bernhard / Susovan Roy Chowdhury / Tsuyoshi Murata / Erin L Reinl / Nokomis Ramos-Gonzalez / Elizabeth Denn / Kevin Appourchaux / Asuka Inoue / Sarah K England / Jonathan F Fay / Susruta Majumdar / Baron Chanda / Tao Che /
PubMed Abstract	The delta opioid receptor (DOR) is a promising target for treating pain, anxiety, and depression, yet no DOR-based drugs have reached the clinic. Here, we examine how ligands with varying therapeutic ...The delta opioid receptor (DOR) is a promising target for treating pain, anxiety, and depression, yet no DOR-based drugs have reached the clinic. Here, we examine how ligands with varying therapeutic properties modulate DOR function. While full agonists rapidly internalize the receptor, partial agonists show a slower rate of internalization, and antagonists increase cell-surface DOR levels. High-resolution structures of ligand-bound DOR-G complexes, including those with antagonists engaged, reveal key interactions that account for DOR ligand selectivity, potency, and efficacy. Single-molecule fluorescence resonance energy transfer studies show that DOR dynamically samples three distinct states (active, obligate preactive, and inactive), and transition rates are tuned by both ligand efficacy and G protein coupling. The endogenous agonist, met-enkephalin, not only stabilizes the active-state conformation but also catalyzes transitions between the active and inactive states. These results reveal how ligand-specific interactions and receptor dynamics can govern pharmacological profiles and provide a framework for developing DOR-targeted therapeutics.
External links	Sci Adv / PubMed:41880505 / PubMed Central
Methods	EM (single particle)
Resolution	3.04 - 3.32 Å
Structure data	71776 9ppw EMDB-71776, PDB-9ppw: CryoEM structure of delta opioid receptor bound to G proteins and Naltrindole Method: EM (single particle) / Resolution: 3.32 Å 71777 9ppx EMDB-71777, PDB-9ppx: CryoEM structure of delta opioid receptor bound to G proteins and naltrexone Method: EM (single particle) / Resolution: 3.04 Å 71778 9ppy EMDB-71778, PDB-9ppy: CryoEM structure of delta opioid receptor bound to G proteins and met-enkephalin Method: EM (single particle) / Resolution: 3.1 Å 71779 9ppz EMDB-71779, PDB-9ppz: CryoEM structure of delta opioid receptor bound to G proteins and SNC80 Method: EM (single particle) / Resolution: 3.19 Å 71780 9pq0 EMDB-71780, PDB-9pq0: CryoEM structure of delta opioid receptor bound to G proteins and ADL5859 Method: EM (single particle) / Resolution: 3.12 Å
Chemicals	ChemComp-EJ4: (4bS,8R,8aS,14bR)-7-(cyclopropylmethyl)-5,6,7,8,14,14b-hexahydro-4,8-methano[1]benzofuro[2,3-a]pyrido[4,3-b]carbazole-1,8a(9H)-diol / antagonistYM PDB-1clj: Unknown entry PDB-1cli: X-RAY CRYSTAL STRUCTURE OF AMINOIMIDAZOLE RIBONUCLEOTIDE SYNTHETASE (PURM), FROM THE E. COLI PURINE BIOSYNTHETIC PATHWAY, AT 2.5 A RESOLUTION PDB-1lxy*: Crystal Structure of Arginine Deiminase covalently linked with L-citrulline
Source	homo sapiens (human) mus musculus (house mouse)
Keywords	MEMBRANE PROTEIN / GPCR / Delta OPIOID Receptor