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TitleDe novo design of potent CRISPR-Cas13 inhibitors
Journal, issue, pagesTo Be Published
Publish dateJan 15, 2025 (structure data deposition date)
AuthorsTaveneau, C. / Chai, X.H. / D'Sivla, J. / Bamert, R.S. / Purcell, J. / Venugopal, H. / Curwen, D. / Munder, F. / Calvert, R. / Hayes, B.K. ...Taveneau, C. / Chai, X.H. / D'Sivla, J. / Bamert, R.S. / Purcell, J. / Venugopal, H. / Curwen, D. / Munder, F. / Calvert, R. / Hayes, B.K. / Martin, L. / Barr, J. / Rosenbluh, J. / Grinter, R. / Knott, G.J.
External linksSearch PubMed
MethodsEM (single particle) / X-ray diffraction
Resolution1.94 - 3.43 Å
Structure data

48668

9mvs

EMDB-48668, PDB-9mvs:
Activated Leptotrichia buccalis (Lbu) CRISPR-Cas13a bound to AI-designed anti-CRISPR AIcrVIA1
Method: EM (single particle) / Resolution: 3.43 Å

PDB-9mvr:
AI-designed Cas13 anti-CRISPR AIcrVIA1
Method: X-RAY DIFFRACTION / Resolution: 1.94 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • synthetic construct (others)
  • leptotrichia buccalis (bacteria)
KeywordsDE NOVO PROTEIN / anti-CRISPR / Acr / CRISPR / Cas13 / DE NOVO PROTEIN/HYDROLASE/RNA / de novo / DE NOVO PROTEIN-HYDROLASE-RNA complex

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