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TitleStructure and Antigenicity of Kaposi's Sarcoma-Associated Herpesvirus Glycoprotein B.
Journal, issue, pagesAdv Sci (Weinh), Vol. 12, Issue 27, Page e2502231, Year 2025
Publish dateApr 26, 2025
AuthorsXin-Yan Fang / Cong Sun / Chu Xie / Bing-Zhen Cheng / Zheng-Zhou Lu / Ge-Xin Zhao / Sen-Fang Sui / Mu-Sheng Zeng / Zheng Liu /
PubMed AbstractKaposi's sarcoma-associated herpesvirus (KSHV), a member of the human γ-herpesviruses family, exhibits extensive cellular tropism and is associated with Kaposi's sarcoma and various B-cell ...Kaposi's sarcoma-associated herpesvirus (KSHV), a member of the human γ-herpesviruses family, exhibits extensive cellular tropism and is associated with Kaposi's sarcoma and various B-cell malignancies. Despite its clinical significance, no effective prophylactic vaccines or specific therapeutics are currently available to prevent or treat KSHV infection. Similar to other herpesviruses, KSHV depends on the envelope glycoprotein B (gB) for host receptor recognition and membrane fusion initiation, making gB a prime target for antiviral antibody or vaccine development. In this study, the high-resolution cryo-electron microscopy (cryo-EM) structure of KSHV gB is presented, revealing a unique trimeric conformation resembling the postfusion state observed in other herpesviruses. Additionally, the structure of the non-neutralizing monoclonal antibody 2C4 bound to KSHV gB domain IV is resolved. The comparative sequence and structure analyses reveal significant homology in neutralizing epitopes between KSHV and Epstein-Barr virus (EBV) gB, indicating a potential pathway for the development of broad-spectrum antiviral strategies. These findings provide a foundation for a deeper understanding of KSHV's infectious mechanism and pave the way for the creation of universal interventions against the human γ-herpesviruses.
External linksAdv Sci (Weinh) / PubMed:40285648 / PubMed Central
MethodsEM (single particle)
Resolution3.0 - 3.6 Å
Structure data

38910

8y48

EMDB-38910, PDB-8y48:
Structure of KSHV glycoprotein B
Method: EM (single particle) / Resolution: 3.26 Å

63198

9lld

EMDB-63198, PDB-9lld:
Post-fusion ectodomain of KSHV gB in complex with 2C4 Fab
Method: EM (single particle) / Resolution: 3.6 Å

EMDB-63209: Local map of interface of KSHV gB and 2C4 fab
Method: EM (single particle) / Resolution: 3.0 Å

Source
  • human gammaherpesvirus 8
  • human herpesvirus 8 strain gk18
  • homo sapiens (human)
KeywordsVIRAL PROTEIN / VIRAL PROTEIN/IMMUNE SYSTEM / KSHV / VIRAL PROTEIN-IMMUNE SYSTEM complex

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