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| Title | Discovery and Validation of a Novel Class of Necroptosis Inhibitors Targeting RIPK1. |
|---|---|
| Journal, issue, pages | Acs Chem. Biol., Vol. 20, Page 1527-1543, Year 2025 |
| Publish date | Sep 17, 2024 (structure data deposition date) |
Authors | Soday, L. / Seripracharat, C. / Gray, J.L. / Luz, A.F.S. / Howard, R.T. / Singh, R. / Burden, T.J. / Bernardini, E. / Mateus-Pinheiro, M. / Petersen, J. ...Soday, L. / Seripracharat, C. / Gray, J.L. / Luz, A.F.S. / Howard, R.T. / Singh, R. / Burden, T.J. / Bernardini, E. / Mateus-Pinheiro, M. / Petersen, J. / Gunnarsson, A. / Gunnarsson, J. / Aagaard, A. / Sjogren, T. / Maslen, S. / Bartlett, E.J. / Iles, A.F. / Smith, D.M. / Scott, J.S. / Skehel, M. / Davis, A.M. / Ressurreicao, A.S. / Moreira, R. / Rodrigues, C.M.P. / Shenoy, A.R. / Tate, E.W. |
External links | Acs Chem. Biol. / PubMed:40539767 |
| Methods | X-ray diffraction |
| Resolution | 2.145 - 2.25 Å |
| Structure data | ![]() PDB-9gtg: ![]() PDB-9gty: |
| Chemicals | ![]() ChemComp-RCM: ![]() PDB-1ipg: ![]() ChemComp-HOH: ![]() ChemComp-DMS: ![]() PDB-1ikx: |
| Source |
|
Keywords | TRANSFERASE / RIPK1 / Kinase / Inhibitor |
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homo sapiens (human)
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