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Title | Identification of Novel Potent NSD2-PWWP1 Ligands Using Structure-Based Design and Computational Approaches. |
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Journal, issue, pages | J. Med. Chem., Vol. 67, Page 8962-8987, Year 2024 |
Publish date | Apr 9, 2024 (structure data deposition date) |
![]() | Carlino, L. / Astles, P.C. / Ackroyd, B. / Ahmed, A. / Chan, C. / Collie, G.W. / Dale, I.L. / O'Donovan, D.H. / Fawcett, C. / di Fruscia, P. ...Carlino, L. / Astles, P.C. / Ackroyd, B. / Ahmed, A. / Chan, C. / Collie, G.W. / Dale, I.L. / O'Donovan, D.H. / Fawcett, C. / di Fruscia, P. / Gohlke, A. / Guo, X. / Hao-Ru Hsu, J. / Kaplan, B. / Milbradt, A.G. / Northall, S. / Petrovic, D. / Rivers, E.L. / Underwood, E. / Webb, A. |
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Methods | X-ray diffraction |
Resolution | 1.699 - 2.43 Å |
Structure data | ![]() PDB-9exw: ![]() PDB-9exx: ![]() PDB-9exy: |
Chemicals | ![]() ChemComp-EDO: ![]() PDB-1h7x: ![]() ChemComp-HOH: ![]() ChemComp-EOH: ![]() PDB-1h7y: ![]() PDB-1h7z: |
Source |
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![]() | TRANSFERASE / Methyl transferase / inhibitor / cancer drug discovery |