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Structure paper

TitleFluorogenic Aptamer Optimization on a Massively Parallel Sequencing Platform.
Journal, issue, pagesACS Sens, Vol. 11, Page 3587-3600, Year 2026
Publish dateNov 22, 2024 (structure data deposition date)
AuthorsKuo, Y.A. / Chen, Y.I. / Siraj, N. / He, Y. / Yang, Z. / Wang, Y. / Batchelder-Schwab, E.J. / Korkmaz, Z. / Yonas, S. / Nguyen, T.D. ...Kuo, Y.A. / Chen, Y.I. / Siraj, N. / He, Y. / Yang, Z. / Wang, Y. / Batchelder-Schwab, E.J. / Korkmaz, Z. / Yonas, S. / Nguyen, T.D. / Hong, S. / Nguyen, A.T. / Kim, S. / Seifi, S. / Fan, P.H. / Wu, Y. / Liu, H.W. / Lu, Y. / Ren, P. / Mao, C. / Yeh, H.C.
External linksACS Sens / PubMed:42112875
MethodsX-ray diffraction
Resolution1.5 - 2.03 Å
Structure data

PDB-9ehb:
Structure of short Lettuce aptamer (C14T variant) bound with TO1-biotin.
Method: X-RAY DIFFRACTION / Resolution: 2.03 Å

PDB-9ehc:
Structure of short Lettuce aptamer bound to TO1-3PEG-Biotin
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-9ehe:
Structure of short Lettuce aptamer (A5T variant) bound with TO1-biotin.
Method: X-RAY DIFFRACTION / Resolution: 1.63 Å

Chemicals

ChemComp-K:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-DMF:
DIMETHYLFORMAMIDE

ChemComp-HZD:
4-[(3-{2,16-dioxo-20-[(3aR,4R,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-6,9,12-trioxa-3,15-diazaicosan-1-yl}-1,3-benzothiazol-3-ium-2-yl)methyl]-1-methylquinolin-1-ium

ChemComp-HOH:
WATER

ChemComp-NA:
Unknown entry

Source
  • synthetic construct (others)
KeywordsDNA / Structure of short Lettuce aptamer (C14T variant) bound with TO1-biotin. / Aptamer / Chromophore / Structure of short Lettuce aptamer (A5T variant) bound with TO1-biotin.

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