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Structure paper

TitleThe small molecule CNS-11g forms amyloid-like fibrils that disassemble pathological alpha-synuclein fibrils
Journal, issue, pagesTo Be Published
Publish dateNov 6, 2024 (structure data deposition date)
AuthorsLu J / Sawaya MR / Cheng XY / Murrali MG / Ge P / Jiang YX / Cascio D / Lutter L / Boyer DR / Williams CK ...Lu J / Sawaya MR / Cheng XY / Murrali MG / Ge P / Jiang YX / Cascio D / Lutter L / Boyer DR / Williams CK / Shino M / Feigon J / Chaturvedi S / Alexandrova A / Eisenberg DS
External linksSearch PubMed
MethodsEM (helical sym.)
Resolution2.6 - 3.5 Å
Structure data

47731

9e8u

EMDB-47731, PDB-9e8u:
(Apo)Alpha-synuclein fibril structures from MSA patient brain
Method: EM (helical sym.) / Resolution: 2.6 Å

47732

9e8v

EMDB-47732, PDB-9e8v:
Complex fibril structure of MSA alpha-synuclein with CNS-11g at 4 hours
Method: EM (helical sym.) / Resolution: 3.0 Å

47733

9e8w

EMDB-47733, PDB-9e8w:
Complex fibril structure of MSA alpha-synuclein with CNS-11g at 6 hours
Method: EM (helical sym.) / Resolution: 2.8 Å

47734

9e8x

EMDB-47734, PDB-9e8x:
Complex fibril structure of MSA alpha-synuclein with CNS-11g at 10 hours
Method: EM (helical sym.) / Resolution: 2.8 Å

47735

9e8y

EMDB-47735, PDB-9e8y:
Complex fibril structure of MSA alpha-synuclein with CNS-11g at 15 hours
Method: EM (helical sym.) / Resolution: 2.9 Å

EMDB-47736: CNS-11g alone fibril
Method: EM (helical sym.) / Resolution: 3.5 Å

Chemicals

PDB-1bgb:
ECORV ENDONUCLEASE COMPLEX WITH 5'-CGGGATATCCC DNA

Source
  • homo sapiens (human)
KeywordsSTRUCTURAL PROTEIN / Multiple system atrophy Type I alpha-synuclein fibrils. / Complex structure of alpha-synuclein type I with small molecule CNS-11g incubated for 4 hours. / Complex structure of alpha-synuclein type I with small molecule CNS11G incubated for 6 hours. / Complex structure of alpha-synuclein type I with small molecule CNS-11g incubated for 10 hours. / Complex structure of alpha-synuclein type I with small molecule CNS-11g incubated for 15 hours.

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