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TitleTeicoplanin Nonribosomal Peptide Synthetase Is Unable to Incorporate Alpha-Ketoacid Building Blocks.
Journal, issue, pagesBiochemistry, Vol. 64, Page 2039-2053, Year 2025
Publish dateOct 7, 2024 (structure data deposition date)
AuthorsRatnayake, M.S. / Jian, X. / Tailhades, J. / Challis, G.L. / Hansen, M.H. / Lewandowski, J.R. / Cryle, M.J.
External linksBiochemistry / PubMed:40215197
MethodsX-ray diffraction
Resolution1.656 Å
Structure data

PDB-9dvh:
A1 Tei + D-Hpg: Adenylation Domain 1 Core Construct from Teicoplanin Biosynthesis with D-4-Hydroxyphenylglycine
Method: X-RAY DIFFRACTION / Resolution: 1.656 Å

Chemicals

ChemComp-GHP:
(2R)-amino(4-hydroxyphenyl)ethanoic acid

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-BO3:
BORIC ACID

ChemComp-HOH:
WATER

Source
  • actinoplanes teichomyceticus (bacteria)
KeywordsLIGASE / AMP-binding enzyme / NRPS / Adenylation domain

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