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TitleEngineered ipilimumab variants that bind human and mouse CTLA-4.
Journal, issue, pagesMabs, Vol. 17, Page 2451296-2451296, Year 2025
Publish dateSep 23, 2024 (structure data deposition date)
AuthorsRobison, B. / Diong, S.J. / Kumar, A. / Moon, T.M. / Chang, O. / Chau, B. / Bee, C. / Barman, I. / Rajpal, A. / Korman, A.J. ...Robison, B. / Diong, S.J. / Kumar, A. / Moon, T.M. / Chang, O. / Chau, B. / Bee, C. / Barman, I. / Rajpal, A. / Korman, A.J. / West, S. / Strop, P. / Lee, P.S.
External linksMabs / PubMed:39849917
MethodsX-ray diffraction
Resolution1.57 - 3.1 Å
Structure data

PDB-9dq3:
Crystal structure of engineered Ipilimumab (mipi.4) Fab in complex with human CTLA-4
Method: X-RAY DIFFRACTION / Resolution: 1.64 Å

PDB-9dq4:
Crystal structure of engineered Ipilimumab (mipi.4) Fab in complex with mouse CTLA-4
Method: X-RAY DIFFRACTION / Resolution: 1.57 Å

PDB-9dq5:
Crystal structure of Anti-CTLA-4 Fab (9D9) in complex with mouse CTLA-4
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsANTITUMOR PROTEIN/IMMUNE SYSTEM / Antibody / CTLA-4 / ANTITUMOR PROTEIN-IMMUNE SYSTEM complex / CTLA-4. ANTITUMOR PROTEIN-IMMUNE SYSTEM complex

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