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TitleActivation of the helper NRC4 immune receptor forms a hexameric resistosome.
Journal, issue, pagesCell, Vol. 187, Issue 18, Page 4877-4889.e15, Year 2024
Publish dateSep 5, 2024
AuthorsFurong Liu / Zhenlin Yang / Chao Wang / Zhang You / Raoul Martin / Wenjie Qiao / Jian Huang / Pierre Jacob / Jeffery L Dangl / Jan E Carette / Sheng Luan / Eva Nogales / Brian J Staskawicz /
PubMed AbstractInnate immune responses to microbial pathogens are regulated by intracellular receptors known as nucleotide-binding leucine-rich repeat receptors (NLRs) in both the plant and animal kingdoms. Across ...Innate immune responses to microbial pathogens are regulated by intracellular receptors known as nucleotide-binding leucine-rich repeat receptors (NLRs) in both the plant and animal kingdoms. Across plant innate immune systems, "helper" NLRs (hNLRs) work in coordination with "sensor" NLRs (sNLRs) to modulate disease resistance signaling pathways. Activation mechanisms of hNLRs based on structures are unknown. Our research reveals that the hNLR, known as NLR required for cell death 4 (NRC4), assembles into a hexameric resistosome upon activation by the sNLR Bs2 and the pathogenic effector AvrBs2. This conformational change triggers immune responses by facilitating the influx of calcium ions (Ca) into the cytosol. The activation mimic alleles of NRC2, NRC3, or NRC4 alone did not induce Ca influx and cell death in animal cells, suggesting that unknown plant-specific factors regulate NRCs' activation in plants. These findings significantly advance our understanding of the regulatory mechanisms governing plant immune responses.
External linksCell / PubMed:39094568 / PubMed Central
MethodsEM (single particle)
Resolution2.66 - 3.54 Å
Structure data

45437

9cc8

EMDB-45437, PDB-9cc8:
Hexameric state of the NRC4 resistosome
Method: EM (single particle) / Resolution: 2.66 Å

45438

9cc9

EMDB-45438, PDB-9cc9:
Dodecameric state of the NRC4 resistosome
Method: EM (single particle) / Resolution: 3.54 Å

Chemicals

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

Source
  • nicotiana benthamiana (plant)
KeywordsPLANT PROTEIN / plant resistosome

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