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-Structure paper
Title | Identification of the Clinical Candidate PF-07284890 ( ARRY-461 ), a Highly Potent and Brain Penetrant BRAF Inhibitor for the Treatment of Cancer. |
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Journal, issue, pages | J. Med. Chem., Vol. 67, Page 13019-13032, Year 2024 |
Publish date | Apr 17, 2024 (structure data deposition date) |
![]() | Ren, L. / Moreno, D. / Baer, B.R. / Barbour, P. / Bettendorf, T. / Bouhana, K. / Brown, K. / Brown, S.A. / Fell, J.B. / Hartley, D.P. ...Ren, L. / Moreno, D. / Baer, B.R. / Barbour, P. / Bettendorf, T. / Bouhana, K. / Brown, K. / Brown, S.A. / Fell, J.B. / Hartley, D.P. / Hicken, E.J. / Laird, E.R. / Lee, P. / McCown, J. / Otten, J.N. / Prigaro, B. / Wallace, R. / Kahn, D. |
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Methods | X-ray diffraction |
Resolution | 1.92 Å |
Structure data | ![]() PDB-9bfb: |
Chemicals | ![]() ChemComp-PEG: ![]() ChemComp-GOL: ![]() PDB-1an9: ![]() ChemComp-HOH: |
Source |
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![]() | SIGNALING PROTEIN / Braf inhibitor / kinase domain |