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TitleStructural insights into isoform-specific RAS-PI3K alpha interactions and the role of RAS in PI3K alpha activation.
Journal, issue, pagesNat Commun, Vol. 16, Page 525-525, Year 2025
Publish dateMar 21, 2024 (structure data deposition date)
AuthorsCzyzyk, D. / Yan, W. / Messing, S. / Gillette, W. / Tsuji, T. / Yamaguchi, M. / Furuzono, S. / Turner, D.M. / Esposito, D. / Nissley, D.V. ...Czyzyk, D. / Yan, W. / Messing, S. / Gillette, W. / Tsuji, T. / Yamaguchi, M. / Furuzono, S. / Turner, D.M. / Esposito, D. / Nissley, D.V. / McCormick, F. / Simanshu, D.K.
External linksNat Commun / PubMed:39788953
MethodsX-ray diffraction
Resolution1.46 - 3.1 Å
Structure data

PDB-9b4q:
Crystal structure of RRAS2 (RAS-Related protein) bound to GMPPNP
Method: X-RAY DIFFRACTION / Resolution: 1.46 Å

PDB-9b4r:
Crystal structure of MRAS bound to GMPPNP
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-9b4s:
Crystal structure of the RRAS2-p110alpha complex
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

PDB-9b4t:
Crystal structure of the MRAS-p110alpha complex
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

PDB-9c15:
Crystal structure of the KRAS-p110alpha complex with molecular glue D927
Method: X-RAY DIFFRACTION / Resolution: 2.81 Å

Chemicals

ChemComp-GNP:
PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER / GppNHp, GMPPNP, energy-carrying molecule analogue*YM

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-ZN:
Unknown entry

ChemComp-5H5:
(2S)-2-({2-[1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}oxy)propanamide

PDB-1atf:
Unknown entry

ChemComp-IPA:
ISOPROPYL ALCOHOL

Source
  • homo sapiens (human)
KeywordsONCOPROTEIN / RAS / RRAS2 / TC21 / RRAS3 / MRAS / p110alpha / PIK3CA / PI3Kalpha / PI3Ka / PI3K / KRAS / glue

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