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Title | Structure-Based Design and Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with High Selectivity, Brain Penetration, and In Vivo Efficacy. |
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Journal, issue, pages | J. Med. Chem., Vol. 67, Page 9431-9446, Year 2024 |
Publish date | Dec 5, 2023 (structure data deposition date) |
![]() | Zheng, J. / Zhang, T. / Tong, S. / Liu, T. / Cui, J. / Xu, H. / Hu, D. / Shen, Y. / Yin, Y. / Zhao, D. ...Zheng, J. / Zhang, T. / Tong, S. / Liu, T. / Cui, J. / Xu, H. / Hu, D. / Shen, Y. / Yin, Y. / Zhao, D. / Tan, C. / Dong, X. / Chen, J. / Ji, F. / Tong, C. / Li, J.J. / Li, J. / Zhang, G. |
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Methods | X-ray diffraction |
Resolution | 1.12 - 1.19 Å |
Structure data | ![]() PDB-8xar: ![]() PDB-8xb0: |
Chemicals | ![]()
ChemComp-YMW: ![]() ChemComp-GOL: ![]() ChemComp-SAM: ![]() ChemComp-EDO: ![]() ChemComp-CL: ![]() ChemComp-HOH: ![]()
ChemComp-YN8: ![]() ChemComp-NA: |
Source |
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![]() | TRANSFERASE / One-carbon metabolism / Metal-binding / inhibitor complex |