Entry Database : PDB / ID : 8xb0 Structure visualization Downloads & linksTitle Structure-Based Design and Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with SAM and Compound 292 ComponentsS-adenosylmethionine synthase isoform type-2 Details Keywords TRANSFERASE / One-carbon metabolism / Metal-binding / inhibitor complexFunction / homology Function and homology informationFunction Domain/homology Component
methionine adenosyltransferase complex / methionine adenosyltransferase / methionine adenosyltransferase activity / Methylation / S-adenosylmethionine biosynthetic process / protein heterooligomerization / protein hexamerization / small molecule binding / cellular response to leukemia inhibitory factor / one-carbon metabolic process ... methionine adenosyltransferase complex / methionine adenosyltransferase / methionine adenosyltransferase activity / Methylation / S-adenosylmethionine biosynthetic process / protein heterooligomerization / protein hexamerization / small molecule binding / cellular response to leukemia inhibitory factor / one-carbon metabolic process / ATP binding / identical protein binding / metal ion binding / cytosol Similarity search - Function S-adenosylmethionine synthetase / S-adenosylmethionine synthetase, N-terminal / S-adenosylmethionine synthetase, central domain / S-adenosylmethionine synthetase, C-terminal / S-adenosylmethionine synthetase, conserved site / S-adenosylmethionine synthetase superfamily / S-adenosylmethionine synthetase, N-terminal domain / S-adenosylmethionine synthetase, central domain / S-adenosylmethionine synthetase, C-terminal domain / S-adenosylmethionine synthase signature 1. / S-adenosylmethionine synthase signature 2. Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.12 Å DetailsAuthors Tong, S.L. / Zhang, G.P. Funding support China, 1items Details Hide detailsOrganization Grant number Country Other private China
CitationJournal : J.Med.Chem. / Year : 2024Title : Structure-Based Design and Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with High Selectivity, Brain Penetration, and In Vivo Efficacy.Authors : Zheng, J. / Zhang, T. / Tong, S. / Liu, T. / Cui, J. / Xu, H. / Hu, D. / Shen, Y. / Yin, Y. / Zhao, D. / Tan, C. / Dong, X. / Chen, J. / Ji, F. / Tong, C. / Li, J.J. / Li, J. / Zhang, G. History Deposition Dec 5, 2023 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Jun 26, 2024 Provider : repository / Type : Initial release