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-Structure paper
Title | Structure-Based Design and Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with High Selectivity, Brain Penetration, and In Vivo Efficacy. |
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Journal, issue, pages | J. Med. Chem., Vol. 67, Page 9431-9446, Year 2024 |
Publish date | Dec 5, 2023 (structure data deposition date) |
Authors | Zheng, J. / Zhang, T. / Tong, S. / Liu, T. / Cui, J. / Xu, H. / Hu, D. / Shen, Y. / Yin, Y. / Zhao, D. ...Zheng, J. / Zhang, T. / Tong, S. / Liu, T. / Cui, J. / Xu, H. / Hu, D. / Shen, Y. / Yin, Y. / Zhao, D. / Tan, C. / Dong, X. / Chen, J. / Ji, F. / Tong, C. / Li, J.J. / Li, J. / Zhang, G. |
External links | J. Med. Chem. / PubMed:38818879 |
Methods | X-ray diffraction |
Resolution | 1.12 - 1.19 Å |
Structure data | PDB-8xar: PDB-8xb0: |
Chemicals |
ChemComp-YMW: ChemComp-GOL: ChemComp-SAM: ChemComp-EDO: ChemComp-CL: ChemComp-HOH:
ChemComp-YN8: ChemComp-NA: |
Source |
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Keywords | TRANSFERASE / One-carbon metabolism / Metal-binding / inhibitor complex |