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-Structure paper
Title | Discovery of Novel 11-Membered Templates as Squalene Synthase Inhibitors. |
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Journal, issue, pages | J. Med. Chem., Vol. 67, Page 5305-5314, Year 2024 |
Publish date | Oct 19, 2023 (structure data deposition date) |
Authors | Haginoya, N. / Suzuki, M. / Ishigai, Y. / Terayama, K. / Kanda, A. / Sugita, K. |
External links | J. Med. Chem. / PubMed:38517948 |
Methods | X-ray diffraction |
Resolution | 2 Å |
Structure data | PDB-8wtq: PDB-8wtr: |
Chemicals | ChemComp-PO4:
ChemComp-KUO: ChemComp-HOH:
ChemComp-KV3: |
Source |
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Keywords | TRANSFERASE / TERPENOID SYNTHASE FOLD / ISOPRENE BIOSYNTHESIS / LIPID SYNTHESIS / MULTIFUNCTIONAL ENZYME / OXIDOREDUCTASE / STEROID BIOSYNTHESIS / STEROL BIOSYNTHESIS / TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX |