Entry Database : PDB / ID : 8wtq Structure visualization Downloads & linksTitle HUMAN SQUALENE SYNTHASE IN COMPLEX WITH {1-[2-Chloro-5-(2,2-dimethyl-propyl)-13-(2-methoxy-phenyl)-6-oxo-6,7,10,11-tetrahydro-5H,9H,13H-12-oxa-5,8-diaza-benzocycloundecene-8-carbonyl]-piperidin-4-yl}-acetic acid ComponentsSqualene synthase Details Keywords TRANSFERASE / TERPENOID SYNTHASE FOLD / ISOPRENE BIOSYNTHESIS / LIPID SYNTHESIS / MULTIFUNCTIONAL ENZYME / OXIDOREDUCTASE / STEROID BIOSYNTHESIS / STEROL BIOSYNTHESIS / TRANSFERASE-TRANSFERASE INHIBITOR COMPLEXFunction / homology Function and homology informationFunction Domain/homology Component
squalene synthase / farnesyl-diphosphate farnesyltransferase activity / farnesyl diphosphate metabolic process / squalene synthase activity / Cholesterol biosynthesis / farnesyltranstransferase activity / steroid biosynthetic process / ergosterol biosynthetic process / cholesterol biosynthetic process / Activation of gene expression by SREBF (SREBP) ... squalene synthase / farnesyl-diphosphate farnesyltransferase activity / farnesyl diphosphate metabolic process / squalene synthase activity / Cholesterol biosynthesis / farnesyltranstransferase activity / steroid biosynthetic process / ergosterol biosynthetic process / cholesterol biosynthetic process / Activation of gene expression by SREBF (SREBP) / PPARA activates gene expression / endoplasmic reticulum membrane / endoplasmic reticulum / membrane / metal ion binding Similarity search - Function Squalene synthase-like / Trans-isoprenyl diphosphate synthases, eukaryotic-type / Squalene and phytoene synthases signature 2. / Squalene/phytoene synthase, conserved site / Squalene and phytoene synthases signature 1. / Squalene/phytoene synthase / Trans-isoprenyl diphosphate synthases, head-to-head / Squalene/phytoene synthase / Isoprenoid synthase domain superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution : 2 Å DetailsAuthors Suzuki, M. / Haginoya, N. / Suzuki, M. / Ishigai, Y. / Terayama, K. / Kanda, A. / Sugita, K. Funding support 1items Details Hide detailsOrganization Grant number Country Not funded
CitationJournal : J.Med.Chem. / Year : 2024Title : Discovery of Novel 11-Membered Templates as Squalene Synthase Inhibitors.Authors : Haginoya, N. / Suzuki, M. / Suzuki, M. / Ishigai, Y. / Terayama, K. / Kanda, A. / Sugita, K. History Deposition Oct 19, 2023 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 May 22, 2024 Provider : repository / Type : Initial release