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Title | Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability. |
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Journal, issue, pages | Antimicrob. Agents Chemother., Vol. 68, Page e0137323-e0137323, Year 2024 |
Publish date | Dec 11, 2023 (structure data deposition date) |
Authors | Mulato, A. / Lansdon, E. / Aoyama, R. / Voigt, J. / Lee, M. / Liclican, A. / Lee, G. / Singer, E. / Stafford, B. / Gong, R. ...Mulato, A. / Lansdon, E. / Aoyama, R. / Voigt, J. / Lee, M. / Liclican, A. / Lee, G. / Singer, E. / Stafford, B. / Gong, R. / Murray, B. / Chan, J. / Lee, J. / Xu, Y. / Ahmadyar, S. / Gonzalez, A. / Cho, A. / Stepan, G.J. / Schmitz, U. / Schultz, B. / Marchand, B. / Brumshtein, B. / Wang, R. / Yu, H. / Cihlar, T. / Xu, L. / Yant, S.R. |
External links | Antimicrob. Agents Chemother. / PubMed:38380945 |
Methods | X-ray diffraction |
Resolution | 1.3 Å |
Structure data | PDB-8vb1: |
Chemicals | PDB-1aad: ChemComp-HOH: |
Source |
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Keywords | VIRAL PROTEIN / HIV / protease / antiviral / inhibitor |