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TitleEnzyme-activating B-cell receptors boost antigen presentation to pathogenic T cells in gluten-sensitive autoimmunity.
Journal, issue, pagesNat Commun, Vol. 16, Page 2387-2387, Year 2025
Publish dateJan 9, 2024 (structure data deposition date)
AuthorsIversen, R. / Heggelund, J.E. / Das, S. / Hoydahl, L.S. / Sollid, L.M.
External linksNat Commun / PubMed:40064932
MethodsX-ray diffraction
Resolution2.803 - 2.9 Å
Structure data

PDB-8rmx:
Transglutaminase 3 in complex with DH patient-derived Fab DH63-A02
Method: X-RAY DIFFRACTION / Resolution: 2.803 Å

PDB-8rmy:
Transglutaminase 3 in complex with inhibitor Z-don and DH patient-derived Fab DH63-A02
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

ChemComp-FLC:
CITRATE ANION

ChemComp-EDO:
1,2-ETHANEDIOL

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsTRANSFERASE / Transglutaminase / autoantibody / dermatitis herpetiformis / tg3 / tgm3 / inhibitor / antibody / calcium

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