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Title | Rational Design of Benzobisheterocycle Metallo-beta-Lactamase Inhibitors: A Tricyclic Scaffold Enhances Potency against Target Enzymes. |
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Journal, issue, pages | J. Med. Chem., Vol. 67, Page 3795-3812, Year 2024 |
Publish date | Nov 17, 2023 (structure data deposition date) |
Authors | Villamil, V. / Rossi, M.A. / Mojica, M.F. / Hinchliffe, P. / Martinez, V. / Castillo, V. / Saiz, C. / Banchio, C. / Macias, M.A. / Spencer, J. ...Villamil, V. / Rossi, M.A. / Mojica, M.F. / Hinchliffe, P. / Martinez, V. / Castillo, V. / Saiz, C. / Banchio, C. / Macias, M.A. / Spencer, J. / Bonomo, R.A. / Vila, A. / Moreno, D.M. / Mahler, G. |
External links | J. Med. Chem. / PubMed:38373290 |
Methods | X-ray diffraction |
Resolution | 1.56 - 1.58 Å |
Structure data | PDB-8r5t: PDB-8r5u: |
Chemicals |
ChemComp-Y4E: ChemComp-ZN: ChemComp-SO4: ChemComp-HOH: ChemComp-FMT: |
Source |
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Keywords | ANTIMICROBIAL PROTEIN / metallo-beta-lactamase / inhibitor |