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TitleIdentification and development of a subtype-selective allosteric AKT inhibitor suitable for clinical development.
Journal, issue, pagesSci Rep, Vol. 12, Page 15715-, Year 2022
Publish dateAug 10, 2023 (structure data deposition date)
AuthorsPage, N. / Wappett, M. / O'Dowd, C.R. / O'Rourke, M. / Gavory, G. / Zhang, L. / Rountree, J.S.S. / Jordan, L. / Barker, O. / Gibson, H. ...Page, N. / Wappett, M. / O'Dowd, C.R. / O'Rourke, M. / Gavory, G. / Zhang, L. / Rountree, J.S.S. / Jordan, L. / Barker, O. / Gibson, H. / Boyd, C. / Feutren-Burton, S. / McLean, E. / Trevitt, G. / Harrison, T.
External linksSci Rep / PubMed:36127435
MethodsX-ray diffraction
Resolution2.32 Å
Structure data

PDB-8q61:
Co-crystal structure of human AKT2 with compound 3
Method: X-RAY DIFFRACTION / Resolution: 2.32 Å

Chemicals

ChemComp-K06:
6-[4-(1-azanyl-3-methyl-3-oxidanyl-cyclobutyl)phenyl]-7-phenyl-1-propyl-pyrido[2,3-b][1,4]oxazin-2-one

ChemComp-GOL:
GLYCEROL

ChemComp-PO4:
PHOSPHATE ION

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Protein Kinase Inhibitor Complex

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