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Structure paper

TitleBroadly neutralizing antibodies isolated from HEV convalescents confer protective effects in human liver-chimeric mice.
Journal, issue, pagesNat Commun, Vol. 16, Page 1995-1995, Year 2025
Publish dateJun 29, 2023 (structure data deposition date)
AuthorsSsebyatika, G. / Dinkelborg, K. / Stroh, L.J. / Hinte, F. / Corneillie, L. / Hueffner, L. / Guzman, E.M. / Nankya, P.L. / Pluckebaum, N. / Fehlau, L. ...Ssebyatika, G. / Dinkelborg, K. / Stroh, L.J. / Hinte, F. / Corneillie, L. / Hueffner, L. / Guzman, E.M. / Nankya, P.L. / Pluckebaum, N. / Fehlau, L. / Garn, J. / Meyer, N. / Prallet, S. / Mehnert, A.K. / Kraft, A.R.M. / Verhoye, L. / Jacobsen, C. / Steinmann, E. / Wedemeyer, H. / Viejo-Borbolla, A. / Dao Thi, V.L. / Pietschmann, T. / Lutgehetmann, M. / Meuleman, P. / Dandri, M. / Krey, T. / Behrendt, P.
External linksNat Commun / PubMed:40011441
MethodsX-ray diffraction
Resolution1.912 - 3.922 Å
Structure data

PDB-8pmw:
HEV gt3 P domain in complex with glycan-sensitive nAb p60.1
Method: X-RAY DIFFRACTION / Resolution: 1.98 Å

PDB-8pmx:
rat HEV P domain in complex with glycan-sensitive nAb p60.12
Method: X-RAY DIFFRACTION / Resolution: 3.922 Å

PDB-8pmy:
HEV gt3 P domain in complex with glycan-insensitive nAb p60.15
Method: X-RAY DIFFRACTION / Resolution: 2.406 Å

PDB-8pmz:
HEV gt3 P domain in complex with glycan-insensitive nAb p61.15
Method: X-RAY DIFFRACTION / Resolution: 1.912 Å

PDB-8pn0:
HEV gt3 P domain in complex with glycan-sensitive nAb p60.12
Method: X-RAY DIFFRACTION / Resolution: 2.072 Å

Chemicals

ChemComp-ACT:
ACETATE ION

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-ZN:
Unknown entry

ChemComp-B3P:
2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

Source
  • homo sapiens (human)
  • hepatitis e virus
  • hepatitis e virus rat/r63/deu/2009
  • paslahepevirus balayani
KeywordsVIRAL PROTEIN / HEV / P domain / non-glycosylated / glycan-sensitive / neutralizing antibody (nAb) / rat HEV / glycan-insensitive

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