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Structure paper

TitleMolecular mechanism of HNF-1A-mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetes.
Journal, issue, pagesJCI Insight, Vol. 9, Year 2024
Publish dateJun 21, 2023 (structure data deposition date)
AuthorsKind, L. / Molnes, J. / Tjora, E. / Raasakka, A. / Myllykoski, M. / Colclough, K. / Saint-Martin, C. / Adelfalk, C. / Dusatkova, P. / Pruhova, S. ...Kind, L. / Molnes, J. / Tjora, E. / Raasakka, A. / Myllykoski, M. / Colclough, K. / Saint-Martin, C. / Adelfalk, C. / Dusatkova, P. / Pruhova, S. / Valtonen-Andre, C. / Bellanne-Chantelot, C. / Arnesen, T. / Kursula, P. / Njolstad, P.R.
External linksJCI Insight / PubMed:38855865
MethodsX-ray diffraction
Resolution2.3 - 3.2 Å
Structure data

PDB-8pi7:
DNA binding domain of HNF-1A bound to P2-HNF4A promoter DNA variant (P2 -169C>T)
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

PDB-8pi8:
DNA binding domain of HNF-1A bound to P2-HNF4A promoter DNA
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-8pi9:
DNA binding domain of HNF-1A bound to P2-HNF4A promoter DNA variant (P2 -181G>A)
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-8pia:
DNA binding domain of HNF-1A bound to P2-HNF4A promoter DNA variant (P2 -181G>T)
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN / Transcription factor / gene transcription / HNF-1A / HNF4A / MODY

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