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Structure paper

TitleStructure and function of the geldanamycin amide synthase from Streptomyces hygroscopicus.
Journal, issue, pagesNat Commun, Vol. 16, Page 2464-2464, Year 2025
Publish dateNov 29, 2022 (structure data deposition date)
AuthorsEwert, W. / Bartens, C. / Ongouta, J. / Holmes, M. / Heutling, A. / Kishore, A. / Urbansky, T. / Zeilinger, C. / Preller, M. / Kirschning, A.
External linksNat Commun / PubMed:40075103
MethodsX-ray diffraction
Resolution1.26 - 1.82 Å
Structure data

PDB-8btm:
Structural and functional studies of geldanamycin amide synthase ShGdmF
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

PDB-8oom:
Structural and functional studies of geldanamycin amide synthase ShGdmF
Method: X-RAY DIFFRACTION / Resolution: 1.82 Å

PDB-8osv:
Structural and functional studies of geldanamycin amide synthase ShGdmF
Method: X-RAY DIFFRACTION / Resolution: 1.28 Å

PDB-8osz:
Structural and functional studies of geldanamycin amide synthase ShGdmF
Method: X-RAY DIFFRACTION / Resolution: 1.26 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

ChemComp-PNY:
(2R)-2,4-dihydroxy-3,3-dimethyl-N-{3-oxo-3-[(2-sulfanylethyl)amino]propyl}butanamide


ChemComp, No image

ChemComp-W0K:
Unknown entry

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-K5V:
3-aminophenol

Source
  • streptomyces hygroscopicus (bacteria)
KeywordsBIOSYNTHETIC PROTEIN / amide synthase / geldanamycin / amidase / alpha-beta

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