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TitleInhibition of VEGF binding to neuropilin-2 enhances chemosensitivity and inhibits metastasis in triple-negative breast cancer.
Journal, issue, pagesSci Transl Med, Vol. 15, Page eadf1128-eadf1128, Year 2023
Publish dateMar 29, 2023 (structure data deposition date)
AuthorsXu, Z. / Goel, H.L. / Burkart, C. / Burman, L. / Chong, Y.E. / Barber, A.G. / Geng, Y. / Zhai, L. / Wang, M. / Kumar, A. ...Xu, Z. / Goel, H.L. / Burkart, C. / Burman, L. / Chong, Y.E. / Barber, A.G. / Geng, Y. / Zhai, L. / Wang, M. / Kumar, A. / Menefee, A. / Polizzi, C. / Eide, L. / Rauch, K. / Rahman, J. / Hamel, K. / Fogassy, Z. / Klopp-Savino, S. / Paz, S. / Zhang, M. / Cubitt, A. / Nangle, L.A. / Mercurio, A.M.
External linksSci Transl Med / PubMed:37134152
MethodsX-ray diffraction
Resolution1.9 - 3.205 Å
Structure data

PDB-8ivw:
Crystal structure of NRP2 in complex with aNRP2-10 Fab fragment
Method: X-RAY DIFFRACTION / Resolution: 3.205 Å

PDB-8ivx:
Crystal structure of NRP2 in complex with aNRP2-14 Fab fragment
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / Complex / Antibody

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