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TitleAllosteric coupling between G-protein binding and extracellular ligand binding sites in GPR52 revealed by F-NMR and cryo-electron microscopy.
Journal, issue, pagesMedComm (2020), Vol. 4, Issue 2, Page e260, Year 2023
Publish dateApr 10, 2023
AuthorsYanliu Fan / Xi Lin / Benxun Pan / Bo Chen / Dongsheng Liu / Kurt Wüthrich / Fei Xu /
External linksMedComm (2020) / PubMed:37051308 / PubMed Central
MethodsEM (single particle)
Resolution2.77 Å
Structure data

34902

8hmp

EMDB-34902, PDB-8hmp:
GPR52 with Gs and c17
Method: EM (single particle) / Resolution: 2.77 Å

Chemicals

ChemComp-EN6:
N-(2-hydroxyethyl)-5-(hydroxymethyl)-3-methyl-1-[2-[[3-(trifluoromethyl)phenyl]methyl]-1-benzothiophen-7-yl]pyrazole-4-carboxamide

Source
  • homo sapiens (human)
KeywordsSTRUCTURAL PROTEIN / GPCR

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