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TitleStructural Basis for the Immunogenicity of the C-Terminus of VP1 of Echovirus 3 Revealed by the Binding of a Neutralizing Antibody.
Journal, issue, pagesViruses, Vol. 14, Issue 11, Year 2022
Publish dateOct 22, 2022
AuthorsShuai Qi / Wangjun Fu / Jinyan Fan / Li Zhang / Binyang Zheng / Kang Wang / Xiangxi Wang / Ling Zhu / Xinjian Li / Yuxia Zhang /
PubMed AbstractEchovirus 3 (E3), a serotype of human enterovirus B (HEV-B), causes severe diseases in infants. Here, we determined the structures of E3 with a monoclonal antibody (MAb) 6D10 by cryo-EM to ...Echovirus 3 (E3), a serotype of human enterovirus B (HEV-B), causes severe diseases in infants. Here, we determined the structures of E3 with a monoclonal antibody (MAb) 6D10 by cryo-EM to comprehensively understand the specificities and the immunological characteristic of this serotype. The solved cryo-EM structures of the F-, A-, and E-particles of E3 bound with 6D10 revealed the structural features of the virus-antibody interface. Importantly, the structures of E-particles bound with 6D10 revealed for the first time the nature of the C-terminus of VP1 for HEV-Bs at the structural level. The highly immunogenic nature of this region in the E-particles provides new strategies for vaccine development for HEV-Bs.
External linksViruses / PubMed:36366420 / PubMed Central
MethodsEM (single particle)
Resolution3.1 - 3.7 Å
Structure data

34231

8gsc

EMDB-34231, PDB-8gsc:
Echovirus3 A-particle in complex with 6D10 Fab
Method: EM (single particle) / Resolution: 3.4 Å

34232

8gsd

EMDB-34232, PDB-8gsd:
Echovirus3 full particle in complex with 6D10 Fab
Method: EM (single particle) / Resolution: 3.1 Å

34233

8gse

EMDB-34233, PDB-8gse:
Echovirus3 capsid protein in complex with 6D10 Fab (upright)
Method: EM (single particle) / Resolution: 3.7 Å

34234

8gsf

EMDB-34234, PDB-8gsf:
Echovirus3 empty particle in complex with 6D10 Fab (sideling)
Method: EM (single particle) / Resolution: 3.6 Å

Chemicals

ChemComp-SPH:
SPHINGOSINE

Source
  • mus musculus (house mouse)
  • echovirus e3
KeywordsVIRUS/IMMUNE SYSTEM / E3 Full particle / Echovirus3 Full particle / antibody / 6D10 / VIRUS-IMMUNE SYSTEM complex / VIRAL PROTEIN/IMMUNE SYSTEM / VIRAL PROTEIN-IMMUNE SYSTEM complex

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