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TitleCryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosis.
Journal, issue, pagesCommun Biol, Vol. 7, Issue 1, Page 905, Year 2024
Publish dateJul 27, 2024
AuthorsBinh An Nguyen / Virender Singh / Shumaila Afrin / Preeti Singh / Maja Pekala / Yasmin Ahmed / Rose Pedretti / Jacob Canepa / Andrew Lemoff / Barbara Kluve-Beckerman / Pawel M Wydorski / Farzeen Chhapra / Lorena Saelices /
PubMed AbstractATTR amyloidosis results from the conversion of transthyretin into amyloid fibrils that deposit in tissues causing organ failure and death. This conversion is facilitated by mutations in ATTRv ...ATTR amyloidosis results from the conversion of transthyretin into amyloid fibrils that deposit in tissues causing organ failure and death. This conversion is facilitated by mutations in ATTRv amyloidosis, or aging in ATTRwt amyloidosis. ATTRv amyloidosis exhibits extreme phenotypic variability, whereas ATTRwt amyloidosis presentation is consistent and predictable. Previously, we found unique structural variabilities in cardiac amyloid fibrils from polyneuropathic ATTRv-I84S patients. In contrast, cardiac fibrils from five genotypically different patients with cardiomyopathy or mixed phenotypes are structurally homogeneous. To understand fibril structure's impact on phenotype, it is necessary to study the fibrils from multiple patients sharing genotype and phenotype. Here we show the cryo-electron microscopy structures of fibrils extracted from four cardiomyopathic ATTRwt amyloidosis patients. Our study confirms that they share identical conformations with minimal structural variability, consistent with their homogenous clinical presentation. Our study contributes to the understanding of ATTR amyloidosis biopathology and calls for further studies.
External linksCommun Biol / PubMed:39068302 / PubMed Central
MethodsEM (helical sym.)
Resolution3.28 - 3.4 Å
Structure data

29874

8g9r

EMDB-29874, PDB-8g9r:
Cardiac amyloid fibrils extracted from a wild-type ATTR amyloidosis patient
Method: EM (helical sym.) / Resolution: 3.28 Å

29920

8gbr

EMDB-29920, PDB-8gbr:
Cardiac amyloid fibrils extracted from a wild-type ATTR amyloidosis patient
Method: EM (helical sym.) / Resolution: 3.4 Å

Source
  • homo sapiens (human)
KeywordsPROTEIN FIBRIL / Transthyretin / Amyloidosis / Systemic amyloidosis / ATTR / Cardiac

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