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Structure paper

TitleMolecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein.
Journal, issue, pagesCell Rep, Vol. 42, Page 113330-113330, Year 2023
Publish dateNov 23, 2022 (structure data deposition date)
AuthorsThai, E. / Murugan, R. / Binter, S. / Burn Aschner, C. / Prieto, K. / Kassardjian, A. / Obraztsova, A.S. / Kang, R.W. / Flores-Garcia, Y. / Mathis-Torres, S. ...Thai, E. / Murugan, R. / Binter, S. / Burn Aschner, C. / Prieto, K. / Kassardjian, A. / Obraztsova, A.S. / Kang, R.W. / Flores-Garcia, Y. / Mathis-Torres, S. / Li, K. / Horn, G.Q. / Huntwork, R.H.C. / Bolscher, J.M. / de Bruijni, M.H.C. / Sauerwein, R. / Dennison, S.M. / Tomaras, G.D. / Zavala, F. / Kellam, P. / Wardemann, H. / Julien, J.P.
External linksCell Rep / PubMed:38007690
MethodsX-ray diffraction
Resolution1.54 - 2.95 Å
Structure data

PDB-8f95:
Crystal structure of Ky15.2 Fab in complex with circumsporozoite protein DND peptide
Method: X-RAY DIFFRACTION / Resolution: 2.45 Å

PDB-8f9e:
Crystal structure of Ky15.2 Fab in complex with circumsporozoite protein KQPA peptide
Method: X-RAY DIFFRACTION / Resolution: 2.95 Å

PDB-8f9f:
Crystal structure of Ky15.2 Fab in complex with circumsporozoite protein NANP3 peptide
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-8f9s:
Crystal structure of Ky15.2 Fab in complex with circumsporozoite protein NDN peptide
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-8f9t:
Crystal structure of Ky15.2 Fab in complex with circumsporozoite protein NPDP peptide
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-8f9u:
Crystal structure of Ky15.7 Fab in complex with circumsporozoite protein NPDP peptide
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-8f9v:
Crystal structure of Ky15.8 Fab in complex with circumsporozoite protein KQPA peptide
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

PDB-8f9w:
Crystal structure of Ky15.8 Fab in complex with circumsporozoite protein NPDP peptide
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-8fa6:
Crystal structure of Ky15.10 Fab in complex with circumsporozoite protein DND peptide
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-8fa7:
Crystal structure of Ky15.11 Fab in complex with circumsporozoite protein KQPA peptide
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-8fa8:
Crystal structure of Ky15.11 Fab in complex with circumsporozoite protein NDN peptide
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-8fa9:
Crystal structure of Ky15.5 Fab in complex with circumsporozoite protein NPDP peptide
Method: X-RAY DIFFRACTION / Resolution: 2.45 Å

PDB-8fan:
Crystal structure of Ky15.1 Fab in complex with circumsporozoite protein KQPA peptide
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-8fas:
Crystal structure of Ky230 Fab in complex with circumsporozoite protein NANP5 peptide
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

PDB-8fat:
Crystal structure of Ky224 Fab in complex with circumsporozoite protein NPDP peptide
Method: X-RAY DIFFRACTION / Resolution: 2.95 Å

PDB-8fb5:
Crystal structure of Ky15.11-S100IK Fab in complex with circumsporozoite protein KQPA peptide
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-8fb6:
Crystal structure of Ky15.10 Fab in complex with circumsporozoite protein KQPA peptide
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

PDB-8fb7:
Crystal structure of Ky15.10 Fab in complex with circumsporozoite protein NPDP peptide
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-8fb8:
Crystal structure of Ky15.10-Y100EK Fab in complex with circumsporozoite protein KQPA peptide
Method: X-RAY DIFFRACTION / Resolution: 1.69 Å

PDB-8fba:
Crystal structure of Ky315 Fab in complex with circumsporozoite protein DND peptide
Method: X-RAY DIFFRACTION / Resolution: 1.96 Å

PDB-8fdc:
Crystal structure of Ky311 Fab in complex with circumsporozoite protein KQPA peptide
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-8fdd:
Crystal structure of Ky15.3 Fab in complex with circumsporozoite protein NPDP peptide
Method: X-RAY DIFFRACTION / Resolution: 1.54 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

Source
  • mus musculus (house mouse)
  • plasmodium falciparum (isolate nf54) (eukaryote)
KeywordsIMMUNE SYSTEM / Malaria / Antibody

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