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TitleDemonstrating the importance of porcine reproductive and respiratory syndrome virus papain-like protease 2 deubiquitinating activity in viral replication by structure-guided mutagenesis.
Journal, issue, pagesPlos Pathog., Vol. 19, Page e1011872-e1011872, Year 2023
Publish dateSep 14, 2022 (structure data deposition date)
AuthorsBailey-Elkin, B.A. / Knaap, R.C.M. / De Silva, A. / Boekhoud, I.M. / Mous, S. / van Vught, N. / Khajehpour, M. / van den Born, E. / Kikkert, M. / Mark, B.L.
External linksPlos Pathog. / PubMed:38096325
MethodsX-ray diffraction
Resolution2.3 - 2.85 Å
Structure data

PDB-8ehn:
PRRSV-1 PLP2 domain
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-8eho:
PRRSV-1 PLP2 domain bound to ubiquitin
Method: X-RAY DIFFRACTION / Resolution: 2.85 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

ChemComp-3CN:
3-AMINOPROPANE

ChemComp-NO3:
NITRATE ION

Source
  • porcine reproductive and respiratory syndrome virus
  • homo sapiens (human)
KeywordsVIRAL PROTEIN / PLP2 / DUB / deubiquitinating

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