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-Structure paper
Title | Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6. |
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Journal, issue, pages | J. Am. Chem. Soc., Vol. 145, Page 10015-10021, Year 2023 |
Publish date | Sep 11, 2022 (structure data deposition date) |
![]() | Van Horn, K.S. / Wang, D. / Medina-Cleghorn, D. / Lee, P.S. / Bryant, C. / Altobelli, C. / Jaishankar, P. / Leung, K.K. / Ng, R.A. / Ambrose, A.J. ...Van Horn, K.S. / Wang, D. / Medina-Cleghorn, D. / Lee, P.S. / Bryant, C. / Altobelli, C. / Jaishankar, P. / Leung, K.K. / Ng, R.A. / Ambrose, A.J. / Tang, Y. / Arkin, M.R. / Renslo, A.R. |
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Methods | X-ray diffraction |
Resolution | 1.82 - 2.14 Å |
Structure data | ![]() PDB-8eg5: ![]() PDB-8eg6: |
Chemicals | ![]() ChemComp-UCI: ![]() ChemComp-EDO: ![]() ChemComp-HOH: ![]() ChemComp-CL: ![]() ChemComp-US9: ![]() ChemComp-PEG: |
Source |
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![]() | APOPTOSIS / HYDROLASE/INHIBITOR / cysteine covalent inhibitor competitive inhibitor protease / PROTEASE-PROTEASE INHIBITOR complex / HYDROLASE-INHIBITOR complex |