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Open data
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Basic information
Entry | Database: PDB / ID: 8eg6 | |||||||||
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Title | huCaspase-6 in complex with inhibitor 2a | |||||||||
![]() | (Caspase-6 subunit ...) x 2 | |||||||||
![]() | APOPTOSIS / HYDROLASE/INHIBITOR / cysteine covalent inhibitor competitive inhibitor protease / PROTEASE-PROTEASE INHIBITOR complex / HYDROLASE-INHIBITOR complex | |||||||||
Function / homology | ![]() caspase-6 / Breakdown of the nuclear lamina / regulation of programmed cell death / positive regulation of necroptotic process / cellular response to staurosporine / cysteine-type endopeptidase activity involved in execution phase of apoptosis / cysteine-type endopeptidase activity involved in apoptotic process / hepatocyte apoptotic process / TP53 Regulates Transcription of Caspase Activators and Caspases / Apoptotic cleavage of cellular proteins ...caspase-6 / Breakdown of the nuclear lamina / regulation of programmed cell death / positive regulation of necroptotic process / cellular response to staurosporine / cysteine-type endopeptidase activity involved in execution phase of apoptosis / cysteine-type endopeptidase activity involved in apoptotic process / hepatocyte apoptotic process / TP53 Regulates Transcription of Caspase Activators and Caspases / Apoptotic cleavage of cellular proteins / pyroptotic inflammatory response / protein autoprocessing / intrinsic apoptotic signaling pathway by p53 class mediator / Caspase-mediated cleavage of cytoskeletal proteins / cysteine-type peptidase activity / epithelial cell differentiation / activation of innate immune response / positive regulation of neuron apoptotic process / positive regulation of apoptotic process / cysteine-type endopeptidase activity / apoptotic process / proteolysis / nucleoplasm / identical protein binding / nucleus / cytoplasm / cytosol Similarity search - Function | |||||||||
Biological species | ![]() | |||||||||
Method | ![]() ![]() ![]() | |||||||||
![]() | Zhao, Y. / Fan, P. / Liu, J. / Wang, Y. / Van Horn, K. / Wang, D. / Medina-Cleghorn, D. / Lee, P. / Bryant, C. / Altobelli, C. ...Zhao, Y. / Fan, P. / Liu, J. / Wang, Y. / Van Horn, K. / Wang, D. / Medina-Cleghorn, D. / Lee, P. / Bryant, C. / Altobelli, C. / Jaishankar, P. / Ng, R.A. / Ambrose, A.J. / Tang, Y. / Arkin, M.R. / Renslo, A.R. | |||||||||
Funding support | ![]()
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![]() | ![]() Title: Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6. Authors: Van Horn, K.S. / Wang, D. / Medina-Cleghorn, D. / Lee, P.S. / Bryant, C. / Altobelli, C. / Jaishankar, P. / Leung, K.K. / Ng, R.A. / Ambrose, A.J. / Tang, Y. / Arkin, M.R. / Renslo, A.R. | |||||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 235.5 KB | Display | ![]() |
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PDB format | ![]() | 186 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 1.5 MB | Display | ![]() |
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Full document | ![]() | 1.5 MB | Display | |
Data in XML | ![]() | 49.6 KB | Display | |
Data in CIF | ![]() | 71.1 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 8eg5C ![]() 3p4uS S: Starting model for refinement C: citing same article ( |
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Similar structure data | Similarity search - Function & homology ![]() |
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Assembly
Deposited unit | ![]()
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Component-ID: _ / Refine code: _
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