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TitleMechanism of Ca transport by ferroportin.
Journal, issue, pagesElife, Vol. 12, Year 2023
Publish dateJan 17, 2023
AuthorsJiemin Shen / Azaan Saalim Wilbon / Ming Zhou / Yaping Pan /
PubMed AbstractFerroportin (Fpn) is a transporter that releases ferrous ion (Fe) from cells and is important for homeostasis of iron in circulation. Export of one Fe by Fpn is coupled to import of two H to maintain ...Ferroportin (Fpn) is a transporter that releases ferrous ion (Fe) from cells and is important for homeostasis of iron in circulation. Export of one Fe by Fpn is coupled to import of two H to maintain charge balance. Here, we show that human Fpn (HsFpn) binds to and mediates Ca transport. We determine the structure of Ca-bound HsFpn and identify a single Ca binding site distinct from the Fe binding sites. Further studies validate the Ca binding site and show that Ca transport is not coupled to transport of another ion. In addition, Ca transport is significantly inhibited in the presence of Fe but not vice versa. Function of Fpn as a Ca uniporter may allow regulation of iron homeostasis by Ca.
External linksElife / PubMed:36648329 / PubMed Central
MethodsEM (single particle)
Resolution3.0 Å
Structure data

27497

8dl6

EMDB-27497, PDB-8dl6:
Cryo-EM structure of human ferroportin/slc40 bound to Ca2+ in nanodisc
Method: EM (single particle) / Resolution: 3.0 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsMEMBRANE PROTEIN / SLC40 / Fpn / ferroportin / iron transporter / calcium / Ca2+ / human / nanodisc

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