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-Structure paper
Title | HIV-1 protease with 10 lopinavir and darunavir resistance mutations exhibits altered inhibition, structural rearrangements and extreme dynamics. |
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Journal, issue, pages | J. Mol. Graph. Model., Vol. 117, Page 108315-108315, Year 2022 |
Publish date | Jun 16, 2022 (structure data deposition date) |
Authors | Wong-Sam, A. / Wang, Y.F. / Kneller, D.W. / Kovalevsky, A.Y. / Ghosh, A.K. / Harrison, R.W. / Weber, I.T. |
External links | J. Mol. Graph. Model. / PubMed:36108568 |
Methods | X-ray diffraction |
Resolution | 1.25 - 1.62 Å |
Structure data | PDB-8dch: PDB-8dci: |
Chemicals | ChemComp-G52: ChemComp-CL: ChemComp-GOL: ChemComp-HOH: |
Source |
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Keywords | VIRAL PROTEIN / HYDROLASE/INHIBITOR / HIV/AIDS / HIV protease / drug resistant clinical mutant / evolution of drug resistance / distal mutations / HYDROLASE-INHIBITOR complex / HYDROLASE |