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-Structure paper
Title | Evaluating the druggability of TrmD, a potential antibacterial target, through design and microbiological profiling of a series of potent TrmD inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 90, Page 129331-129331, Year 2023 |
Publish date | Aug 10, 2022 (structure data deposition date) |
Authors | Wilkinson, A.J. / Ooi, N. / Finlayson, J. / Lee, V.E. / Lyth, D. / Maskew, K.S. / Newman, R. / Orr, D. / Ansell, K. / Birchall, K. ...Wilkinson, A.J. / Ooi, N. / Finlayson, J. / Lee, V.E. / Lyth, D. / Maskew, K.S. / Newman, R. / Orr, D. / Ansell, K. / Birchall, K. / Canning, P. / Coombs, P. / Fusani, L. / McIver, E. / Pisco, J. / Ireland, P.M. / Jenkins, C. / Norville, I.H. / Southern, S.J. / Cowan, R. / Hall, G. / Kettleborough, C. / Savage, V.J. / Cooper, I.R. |
External links | Bioorg. Med. Chem. Lett. / PubMed:37187252 |
Methods | X-ray diffraction |
Resolution | 1.8 - 2.4 Å |
Structure data | PDB-8apt: PDB-8apu: PDB-8apv: PDB-8apw: |
Chemicals | ChemComp-NN9: ChemComp-CIT: ChemComp-HOH: ChemComp-NMV: ChemComp-NLL: ChemComp-NL1: |
Source |
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Keywords | RNA BINDING PROTEIN / Methyltransferase |