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TitleStructural insights into 3Fe-4S ferredoxins diversity in M. tuberculosis highlighted by a first redox complex with P450.
Journal, issue, pagesFront Mol Biosci, Vol. 9, Page 1100032-1100032, Year 2022
Publish dateAug 3, 2022 (structure data deposition date)
AuthorsGilep, A. / Varaksa, T. / Bukhdruker, S. / Kavaleuski, A. / Ryzhykau, Y. / Smolskaya, S. / Sushko, T. / Tsumoto, K. / Grabovec, I. / Kapranov, I. ...Gilep, A. / Varaksa, T. / Bukhdruker, S. / Kavaleuski, A. / Ryzhykau, Y. / Smolskaya, S. / Sushko, T. / Tsumoto, K. / Grabovec, I. / Kapranov, I. / Okhrimenko, I. / Marin, E. / Shevtsov, M. / Mishin, A. / Kovalev, K. / Kuklin, A. / Gordeliy, V. / Kaluzhskiy, L. / Gnedenko, O. / Yablokov, E. / Ivanov, A. / Borshchevskiy, V. / Strushkevich, N.
External linksFront Mol Biosci / PubMed:36699703
MethodsX-ray diffraction
Resolution1.4 - 2 Å
Structure data

PDB-8amo:
Crystal structure of M. tuberculosis CYP143
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

PDB-8amp:
Crystal structure of M.tuberculosis ferredoxin Fdx
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-8amq:
Crystal structure of the complex CYP143-FdxE from M. tuberculosis
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-CL:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-F3S:
FE3-S4 CLUSTER

ChemComp-FE:
Unknown entry

ChemComp-NI:
NICKEL (II) ION

Source
  • mycobacterium tuberculosis h37rv (bacteria)
  • mycobacterium tuberculosis (bacteria)
KeywordsOXIDOREDUCTASE / M. tuberculosis / cytochrome P450 / rv1785c / ELECTRON TRANSPORT / Ferredoxin / tuberculosis / Rv0763c / CYP51 / redox partner / Rv1786 / fusion / chimera

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