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Structure paper

TitleStructural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy.
Journal, issue, pagesNat Commun, Vol. 16, Page 1596-1596, Year 2025
Publish dateDec 1, 2017 (structure data deposition date)
AuthorsNewman, J.A. / Gavard, A.E. / Imprachim, N. / Aitkenhead, H. / Sheppard, H.E. / Te Poele, R. / Clarke, P.A. / Hossain, M.A. / Temme, L. / Oh, H.J. ...Newman, J.A. / Gavard, A.E. / Imprachim, N. / Aitkenhead, H. / Sheppard, H.E. / Te Poele, R. / Clarke, P.A. / Hossain, M.A. / Temme, L. / Oh, H.J. / Wells, C.I. / Davis-Gilbert, Z.W. / Workman, P. / Gileadi, O. / Drewry, D.H.
External linksNat Commun / PubMed:39952925
MethodsX-ray diffraction
Resolution1.49 - 2.55 Å
Structure data

PDB-6f58:
Crystal structure of human Brachyury (T) in complex with DNA
Method: X-RAY DIFFRACTION / Resolution: 2.253 Å

PDB-6f59:
Crystal structure of human Brachyury (T) G177D variant in complex with DNA
Method: X-RAY DIFFRACTION / Resolution: 2.151 Å

PDB-7zk2:
Crystal Structure of human Brachyury G177D variant in complex with CSC027898502
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-7zkf:
Crystal Structure of human Brachyury G177D variant in complex with CF-5-86
Method: X-RAY DIFFRACTION / Resolution: 1.49 Å

PDB-7zl2:
Crystal Structure of human Brachyury G177D variant in complex with Molpolrt-039-246-810
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-8a10:
Crystal Structure of human Brachyury G177D variant in complex with Molpolrt-020-049-143
Method: X-RAY DIFFRACTION / Resolution: 1.88 Å

PDB-8a7n:
Crystal Structure of human Brachyury G177D variant in complex with (S)-N-(3-aminopropyl)-3-((1-(2-fluorophenyl)-2-oxopyrrolidin-3-yl)amino)-N-methylbenzamide (CF-2-125)
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-8cdn:
Crystal structure of human Brachyury in complex with a single T box binding element DNA
Method: X-RAY DIFFRACTION / Resolution: 2.55 Å

Chemicals

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-PO4:
PHOSPHATE ION

ChemComp-IU4:
N-[4-(2-morpholin-4-yl-1,3-thiazol-4-yl)phenyl]ethanamide

PDB-1i1t:
Unknown entry


ChemComp, No image

ChemComp-IXB:
Unknown entry

PDB-1iyk:
Crystal structure of candida albicans N-myristoyltransferase with myristoyl-COA and peptidic inhibitor

ChemComp-L9E:
N-(3-azanylpropyl)-3-[[(3S)-1-(2-fluorophenyl)-2-oxidanylidene-pyrrolidin-3-yl]amino]-N-methyl-benzamide

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / chordoma / Brachyury / T-box / TBXT / transcription factor

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