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| Title | Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106 . |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 65, Page 9206-9229, Year 2022 |
| Publish date | Apr 11, 2022 (structure data deposition date) |
 Authors | Heinrich, T. / Peterson, C. / Schneider, R. / Garg, S. / Schwarz, D. / Gunera, J. / Seshire, A. / Kotzner, L. / Schlesiger, S. / Musil, D. ...Heinrich, T. / Peterson, C. / Schneider, R. / Garg, S. / Schwarz, D. / Gunera, J. / Seshire, A. / Kotzner, L. / Schlesiger, S. / Musil, D. / Schilke, H. / Doerfel, B. / Diehl, P. / Bopple, P. / Lemos, A.R. / Sousa, P.M.F. / Freire, F. / Bandeiras, T.M. / Carswell, E. / Pearson, N. / Sirohi, S. / Hooker, M. / Trivier, E. / Broome, R. / Balsiger, A. / Crowden, A. / Dillon, C. / Wienke, D. |
 External links | J. Med. Chem. / PubMed:35763499 |
| Methods | X-ray diffraction |
| Resolution | 2.095 - 2.19 Å |
| Structure data |  PDB-7zjp:  PDB-7zjq: |
| Chemicals |  ChemComp-JJU:  ChemComp-SO4:  ChemComp-HOH:  ChemComp-JIK: |
| Source |
|
 Keywords | TRANSCRIPTION / IMMUNOGLOBULIN-LIKE FOLD / ACTIVATOR / DISEASE MUTATION / DNA-BINDING / NUCLEUS / PHOSPHOPROTEIN / TRANSCRIPTION REGULATION / TRANSCRIPTION-PROTEIN BINDING COMPLEX |
homo sapiens (human)