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-Structure paper
Title | Development of selective inhibitors of phosphatidylinositol 3-kinase C2 alpha. |
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Journal, issue, pages | Nat. Chem. Biol., Vol. 19, Page 18-27, Year 2023 |
Publish date | Mar 15, 2022 (structure data deposition date) |
Authors | Lo, W.T. / Belabed, H. / Kucukdisli, M. / Metag, J. / Roske, Y. / Prokofeva, P. / Ohashi, Y. / Horatscheck, A. / Cirillo, D. / Krauss, M. ...Lo, W.T. / Belabed, H. / Kucukdisli, M. / Metag, J. / Roske, Y. / Prokofeva, P. / Ohashi, Y. / Horatscheck, A. / Cirillo, D. / Krauss, M. / Schmied, C. / Neuenschwander, M. / von Kries, J.P. / Medard, G. / Kuster, B. / Perisic, O. / Williams, R.L. / Daumke, O. / Payrastre, B. / Severin, S. / Nazare, M. / Haucke, V. |
External links | Nat. Chem. Biol. / PubMed:36109648 |
Methods | X-ray diffraction |
Resolution | 2.5 - 2.87 Å |
Structure data | PDB-7z74: PDB-7z75: PDB-8a9i: |
Chemicals | ChemComp-IKC: ChemComp-EDO: ChemComp-HOH: ChemComp-IG3: ChemComp-SO4: ChemComp-TSW: |
Source |
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Keywords | TRANSFERASE / PI3KC2 alpha / kinase |