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Structure paper

TitleType B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.
Journal, issue, pagesPlos Pathog., Vol. 18, Page e1010328-e1010328, Year 2022
Publish dateMar 3, 2022 (structure data deposition date)
AuthorsKrischuns, T. / Isel, C. / Drncova, P. / Lukarska, M. / Pflug, A. / Paisant, S. / Navratil, V. / Cusack, S. / Naffakh, N.
External linksPlos Pathog. / PubMed:35605026
MethodsX-ray diffraction
Resolution2.418 - 3.412 Å
Structure data

PDB-7z42:
Influenza B polymerase with Pol II pSer5 CTD peptide mimic bound in site 2B
Method: X-RAY DIFFRACTION / Resolution: 2.418 Å

PDB-7z43:
Influenza B polymerase with Pol II pSer5 CTD peptide mimic bound in site 1B and 2B
Method: X-RAY DIFFRACTION / Resolution: 3.123 Å

PDB-7z4o:
Influenza A/H7N9 polymerase core dimer with Pol II pSer5 CTD peptide mimic bound in site 2A
Method: X-RAY DIFFRACTION / Resolution: 3.412 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-PO4:
PHOSPHATE ION

ChemComp-IC5:
[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphono hydrogen phosphate

ChemComp-MG:
Unknown entry

Source
  • influenza b virus
  • homo sapiens (human)
  • influenza a virus
KeywordsRNA BINDING PROTEIN / Influenza RNA-dependent RNA polymerase / transcription / cap-snatching / Pol II CTD

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