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TitleThe Bispecific Tumor Antigen-Conditional 4-1BB x 5T4 Agonist, ALG.APV-527, Mediates Strong T-Cell Activation and Potent Antitumor Activity in Preclinical Studies.
Journal, issue, pagesMol. Cancer Ther., Vol. 22, Page 89-101, Year 2023
Publish dateFeb 16, 2022 (structure data deposition date)
AuthorsNelson, M.H. / Fritzell, S. / Miller, R. / Werchau, D. / Van Citters, D. / Nilsson, A. / Misher, L. / Ljung, L. / Bader, R. / Deronic, A. ...Nelson, M.H. / Fritzell, S. / Miller, R. / Werchau, D. / Van Citters, D. / Nilsson, A. / Misher, L. / Ljung, L. / Bader, R. / Deronic, A. / Chunyk, A.G. / Schultz, L. / Varas, L.A. / Rose, N. / Hakansson, M. / Gross, J. / Furebring, C. / Pavlik, P. / Sundstedt, A. / Veitonmaki, N. / Ramos, H.J. / Sall, A. / Dahlman, A. / Bienvenue, D. / von Schantz, L. / McMahan, C.J. / Askmyr, M. / Hernandez-Hoyos, G. / Ellmark, P.
External linksMol. Cancer Ther. / PubMed:36343381
MethodsX-ray diffraction
Resolution2.31 Å
Structure data

PDB-7yxu:
Crystal structure of agonistic antibody 1618 fab domain bound to human 4-1BB.
Method: X-RAY DIFFRACTION / Resolution: 2.31 Å

Chemicals

ChemComp-TMO:
trimethylamine oxide

ChemComp-MN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / complex / Fab / tumor necrosis factor

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