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Structure paper

TitleImmunoglobulin M perception by FcμR.
Journal, issue, pagesNature, Vol. 615, Issue 7954, Page 907-912, Year 2023
Publish dateMar 22, 2023
AuthorsYaxin Li / Hao Shen / Ruixue Zhang / Chenggong Ji / Yuxin Wang / Chen Su / Junyu Xiao /
PubMed AbstractImmunoglobulin M (IgM) is the first antibody to emerge during embryonic development and the humoral immune response. IgM can exist in several distinct forms, including monomeric, membrane-bound IgM ...Immunoglobulin M (IgM) is the first antibody to emerge during embryonic development and the humoral immune response. IgM can exist in several distinct forms, including monomeric, membrane-bound IgM within the B cell receptor (BCR) complex, pentameric and hexameric IgM in serum and secretory IgM on the mucosal surface. FcμR, the only IgM-specific receptor in mammals, recognizes different forms of IgM to regulate diverse immune responses. However, the underlying molecular mechanisms remain unknown. Here we delineate the structural basis of the FcμR-IgM interaction by crystallography and cryo-electron microscopy. We show that two FcμR molecules interact with a Fcμ-Cμ4 dimer, suggesting that FcμR can bind to membrane-bound IgM with a 2:1 stoichiometry. Further analyses reveal that FcμR-binding sites are accessible in the context of IgM BCR. By contrast, pentameric IgM can recruit four FcμR molecules to bind on the same side and thereby facilitate the formation of an FcμR oligomer. One of these FcμR molecules occupies the binding site of the secretory component. Nevertheless, four FcμR molecules bind to the other side of secretory component-containing secretory IgM, consistent with the function of FcμR in the retrotransport of secretory IgM. These results reveal intricate mechanisms of IgM perception by FcμR.
External linksNature / PubMed:36949194
MethodsEM (single particle) / X-ray diffraction
Resolution3 - 3.71 Å
Structure data

34074

7ysg

EMDB-34074, PDB-7ysg:
Cryo-EM structure of human FcmR bound to sIgM
Method: EM (single particle) / Resolution: 3.18 Å

34085

7ytc

EMDB-34085, PDB-7ytc:
Cryo-EM structure of human FcmR bound to IgM-Fc/J
Method: EM (single particle) / Resolution: 3.39 Å

34086

7ytd

EMDB-34086, PDB-7ytd:
Cryo-EM structure of four human FcmR bound to IgM-Fc/J
Method: EM (single particle) / Resolution: 3.71 Å

PDB-7yte:
crystal structure of human FcmR-D1 bound to IgM C4-domain
Method: X-RAY DIFFRACTION / Resolution: 3.0 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / immunoglobin M / FcmR

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