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-Structure paper
Title | Design, synthesis, and structure-activity relationship of TAK-418 and its derivatives as a novel series of LSD1 inhibitors with lowered risk of hematological side effects. |
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Journal, issue, pages | Eur. J. Med. Chem., Vol. 239, Page 114522-114522, Year 2022 |
Publish date | May 26, 2022 (structure data deposition date) |
![]() | Hattori, Y. / Matsumoto, S. / Morimoto, S. / Daini, M. / Toyofuku, M. / Matsuda, S. / Baba, R. / Murakami, K. / Iwatani, M. / Oki, H. ...Hattori, Y. / Matsumoto, S. / Morimoto, S. / Daini, M. / Toyofuku, M. / Matsuda, S. / Baba, R. / Murakami, K. / Iwatani, M. / Oki, H. / Iwasaki, S. / Matsumiya, K. / Tominari, Y. / Kimura, H. / Ito, M. |
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Methods | X-ray diffraction |
Resolution | 2.28 Å |
Structure data | ![]() PDB-7xw8: |
Chemicals | ![]() ChemComp-GOL: ![]() ChemComp-MG: ![]() ChemComp-FA8: ![]() ChemComp-I00: ![]() ChemComp-HOH: |
Source |
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![]() | OXIDOREDUCTASE / Inhibitor / TAK-418 / distomer / FAD-adduct |