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-Structure paper
Title | N -Acylamino Saccharin as an Emerging Cysteine-Directed Covalent Warhead and Its Application in the Identification of Novel FBPase Inhibitors toward Glucose Reduction. |
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Journal, issue, pages | J. Med. Chem., Vol. 65, Page 9126-9143, Year 2022 |
Publish date | Jan 8, 2022 (structure data deposition date) |
![]() | Wen, W. / Cao, H. / Xu, Y. / Ren, Y. / Rao, L. / Shao, X. / Chen, H. / Wu, L. / Liu, J. / Su, C. ...Wen, W. / Cao, H. / Xu, Y. / Ren, Y. / Rao, L. / Shao, X. / Chen, H. / Wu, L. / Liu, J. / Su, C. / Peng, C. / Huang, Y. / Wan, J. |
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Methods | X-ray diffraction |
Resolution | 1.724 Å |
Structure data | ![]() PDB-7wjv: |
Chemicals | ![]() ChemComp-AMP: ![]() ChemComp-LSA: ![]() ChemComp-MG: ![]() ChemComp-PMQ: ![]() ChemComp-GOL: ![]() ChemComp-HOH: |
Source |
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![]() | CYTOSOLIC PROTEIN / Classification: HYDROLASE Organism(s): Homo sapiens Expression System: Escherichia coli BL21(DE3) inhibitor: covalent binding C128 |