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-Structure paper
Title | Structure-Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2 |
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Journal, issue, pages | Acs Med. Chem. Lett., Vol. 13, Page 1485-1492, Year 2022 |
Publish date | Nov 25, 2021 (structure data deposition date) |
![]() | Niwa, H. / Watanabe, C. / Sato, S. / Harada, T. / Watanabe, H. / Tabusa, R. / Fukasawa, S. / Shiobara, A. / Hashimoto, T. / Ohno, O. ...Niwa, H. / Watanabe, C. / Sato, S. / Harada, T. / Watanabe, H. / Tabusa, R. / Fukasawa, S. / Shiobara, A. / Hashimoto, T. / Ohno, O. / Nakamura, K. / Tsuganezawa, K. / Tanaka, A. / Shirouzu, M. / Honma, T. / Matsuno, K. / Umehara, T. |
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Methods | X-ray diffraction |
Resolution | 2.05 - 2.82 Å |
Structure data | ![]() PDB-7w3l: ![]() PDB-7xe1: ![]() PDB-7xe2: ![]() PDB-7xe3: |
Chemicals | ![]() ChemComp-FAD: ![]() ChemComp-8A2: ![]() ChemComp-TLA: ![]() ChemComp-GOL: ![]() ChemComp-HOH: ![]() ChemComp-ZN: ![]() ChemComp-DIJ: ![]() ChemComp-FLC: ![]() ChemComp-PGE: ![]() ChemComp-PEG: ![]() ChemComp-PG4: ![]() ChemComp-EDO: |
Source |
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![]() | OXIDOREDUCTASE / DEMETHYLASE / AMINE OXIDASE / CHROMATIN / HISTONE / FAD / MECHANISM-BASED INHIBITOR |