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TitleSerine hydroxymethyltransferase as a potential target of antibacterial agents acting synergistically with one-carbon metabolism-related inhibitors.
Journal, issue, pagesCommun Biol, Vol. 5, Page 619-619, Year 2022
Publish dateAug 10, 2021 (structure data deposition date)
AuthorsMakino, Y. / Oe, C. / Iwama, K. / Suzuki, S. / Nishiyama, A. / Hasegawa, K. / Okuda, H. / Hirata, K. / Ueno, M. / Kawaji, K. ...Makino, Y. / Oe, C. / Iwama, K. / Suzuki, S. / Nishiyama, A. / Hasegawa, K. / Okuda, H. / Hirata, K. / Ueno, M. / Kawaji, K. / Sasano, M. / Usui, E. / Hosaka, T. / Yabuki, Y. / Shirouzu, M. / Katsumi, M. / Murayama, K. / Hayashi, H. / Kodama, E.N.
External linksCommun Biol / PubMed:35739195
MethodsX-ray diffraction
Resolution1.9 - 2.62 Å
Structure data

PDB-7v3d:
Complex structure of serine hydroxymethyltransferase from Enterococcus faecium and its inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.28 Å

PDB-7x5n:
Crystal structure of E. faecium SHMT in complex with (+)-SHIN-1 and PLP-Ser
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-7x5o:
Crystal structure of E. faecium SHMT in complex with Me-THF and PLP-Gly
Method: X-RAY DIFFRACTION / Resolution: 2.62 Å

Chemicals

ChemComp-5M5:
(4R)-6-azanyl-4-[3-(hydroxymethyl)-5-phenyl-phenyl]-3-methyl-4-propan-2-yl-1H-pyrano[2,3-c]pyrazole-5-carbonitrile

ChemComp-PLP:
PYRIDOXAL-5'-PHOSPHATE

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-PLS:
[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-SERINE

ChemComp-THH:
N-[4-({[(6S)-2-AMINO-4-HYDROXY-5-METHYL-5,6,7,8-TETRAHYDROPTERIDIN-6-YL]METHYL}AMINO)BENZOYL]-L-GLUTAMIC ACID

ChemComp-PLG:
N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE]

Source
  • enterococcus faecium (bacteria)
KeywordsTRANSFERASE / inhibitor / Antibacterial mechanism / complex / E. faecium / Serine hydroxymethyltransferase / 1C metabolism

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